异甘草素对创伤性脑损伤大鼠损伤灶修复作用的实验研究
《创伤外科杂志》[ISSN:/CN:]
- 期数:
- 2014年16卷03期
- 页码:
- 144-146
- 栏目:
- 基础研究
- 出版日期:
- 2014-05-14
文章信息/Info
- Title:
- Repairing effects of isoliquiritigenin on traumatic brain injury in rats
- Author(s):
- YANG Yongming; LI Zhiyun
- Department of Neurosurgery,Lanzhou General Hospital,Lanzhou Military Command,Lanzhou 730050,China
- 分类号:
- R 651
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 【摘要】目的 观察异甘草素对创伤性脑损伤大鼠病理变化和血清白介素-1α（IL-1α）、IL-1β、IL-6、IL-10和肿瘤坏死因子-α（TNFα）的影响，探讨其在创伤性脑损伤（TBI）后促进脑损伤灶康复的作用机制。方法 运用改良Feeney法建立大鼠脑损伤模型，将动物随机分为假手术组、脑损伤组、异甘草素治疗组，共治疗5d，经平衡木行走试验观察神经行为学变化后处死，采用蛋白芯片法检测血清中的细胞因子，HE染色光镜下观察损伤灶的变化。结果 与脑外伤组相比异甘草素治疗组 IL-1α、IL-6、IL-10的血清含量明显增高，IL-1β和TNFα的含量显著降低（P<0.05），损伤灶病理学变化明显改善。结论 异甘草素可以促进创伤性脑损伤大鼠脑损伤灶康复，其机制可能与调节细胞因子有关。
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备注/Memo
- 备注/Memo:
- 基金项目：2012解放军总后勤科研项目（CLZ12J006）
