黄体酮对重度颅脑损伤患者血清TNFα、IL 1β和预后的影响
《创伤外科杂志》[ISSN:/CN:]
- 期数:
- 2012年14卷02期
- 页码:
- 157-160
- 栏目:
- 基础研究
- 出版日期:
- 2012-04-20
文章信息/Info
- Title:
- Effect of progesterone on serum TNFα,IL1β and prognosis in patients with severe traumatic brain injury
- 作者:
- 陆林其; 盛罗平; 李季林; 陈仁辉; 朱卫
- 基金项目：上海市青浦区卫生局资助（qw2009-2） 作者单位：201700上海，复旦大学附属中山医院青浦分院神经外科（陆林其，盛罗平，李季林，陈仁辉）；2.复旦大学附属中山医院神经外科（朱卫）
- Author(s):
- LU Linqi1; SHENG Luoping1; LI Jilin1; CHEN Renhui1; ZHU Wei2
- 1.Department of Neurosurgery，Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai〓201700,China;2.Department of Neurosurgery,Zhongshan Hospital,Fudan University,Shanghai〓200032,China
- 分类号:
- R 651.15
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 【摘要】〓目的〓〖HTSS〗探索黄体酮对重度颅脑损伤（TBI）患者血清中炎症因子肿瘤坏死因子α(TNFα)、白细胞介素1β（IL1β）的影响及临床意义。〖HTH〗方法〓〖HTSS〗将65例重度颅脑损伤（TBI）患者按完全随机分组方法分为对照组和黄体酮组。对照组行必要的神经外科处理及常规药物治疗；黄体酮组在上述治疗的基础上，加用黄体酮治疗，1.0mg/（kg?d），连用3d。采用酶联免疫吸附测定法（ELISA）检测两组患者伤后第1、3、5天血清中TNFα、IL1β的含量。伤后3个月采用格拉斯哥预后评分（GOS）对患者预后进行评估。〖HTH〗结果〓〖HTSS〗伤后第1天TNFα、IL1β的含量黄体酮组和对照组无明显差异（P>0.05），均和正常对照组有差异（P<0.05）。伤后第3、5天，TNFα、IL1β的含量黄体酮组下降较对照组明显（P<0.05）。伤后3个月GOS评估结果显示，黄体酮组预后良好患者明显多于对照组(P<0.05)。〖HTH〗结论〓〖HTSS〗黄体酮治疗颅脑损伤患者可以降低血清TNFα、IL1β含量，促进神经功能的恢复，提高临床疗效。
参考文献/References
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备注/Memo
- 备注/Memo:
- -
