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聚多巴胺仿生法制备羟基磷灰石涂层对多孔钽骨整合 影响的体内研究

《创伤外科杂志》[ISSN:/CN:]

期数:
2020年09期
页码:
675-680
栏目:
论著（基础研究）
出版日期:
2020-09-20

文章信息/Info

Title:
Effect of polydopamine-induced hydroxyapatite coating on osseointegration of porous tantalum: an in vivo study
作者:
徐炎安; 彭海涛; 曾清明; 黄光斌
400014 重庆,重庆市急救医疗中心,重庆大学附属中心医院创伤科(徐炎安,黄光斌); 600015 成都,四川大学物理学院(彭海涛); 402260 重庆,潼南区人民医院骨科(曾清明)
Author(s):
XU Yan-an1; PENG Hai-tao2; ZENG Qing-ming3; HUANG Guang-bin1
1.Department of Trauma Surgery,Emergency Medical Cental of Chongqing,The Affiliated Central Hospital of Chongqing University,Chongqing 400014,China; 2.College of Physical Science and Technology,Sichuan University,Chengdu 610015,China; 3.Department of Orthopedics,Tongnan People's Hospital of Chongqing,Chongqing 402260,China
关键词:
骨缺损;  多孔钽;  聚多巴胺;  羟基磷灰石涂层;  骨整合;  兔
分类号:
R 318.08
DOI:
10.3969j.issn.1009-4237.2020.09.008
文献标识码:
A
摘要:
目的 研究聚多巴胺仿生法制备羟基磷灰石(hydroxyapatite,HA)涂层对多孔钽骨整合能力的影响。方法 选用成年雄性新西兰兔30只作为实验动物,体重2.1～2.8kg,在新西兰兔双侧股骨外踝处建立骨缺损模型,每只动物左右侧缺损随机分组,分别植入含HA涂层(实验组)和不含HA涂层(对照组)多孔钽材料,各30个,通过聚多巴胺仿生法制备HA涂层,植入后1、4、8周取材,通过X线片检测以及硬组织切片HE染色检测多孔钽与骨界面的骨整合情况。采用推出实验检测多孔钽与骨界面的结合强度。结果 术后1、4周X线片示两组材料界面的新生骨组织逐渐增加,而实验组周围新生骨量显著多于对照组。术后4、8周硬组织切片示两组材料周围均有较多新生骨小梁形成并向材料孔隙内生长,但实验组新生骨小梁的量和深度显著强于对照组。植入4周时实验组与对照组组织切片定量分别为(28.6±4.1)和(22.3±1.7),植入8周时分别为(57.6±6.8)和(33.5±4.3),P<0.05; 推出实验显示实验组材料与骨组织界面结合强度显著强于对照组,植入4周时实验组与对照组分别为(81.3±9.3)N和(63.1±11.2)N,植入8周时分别为(115.6±10.1)N和(87.5±9.6)N,P<0.05。结论 聚多巴胺仿生法制备HA涂层能够提高多孔钽的骨整合能力。

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备注/Memo

备注/Memo:
【基金项目】 重庆市卫计委医学科研项目(2016HBRC007) 【通信作者】 黄光斌,E-mail:hgbin563@163.com
更新日期/Last Update: 2020-09-20