血浆NGAL在创伤脓毒症诊断中的作用研究
《创伤外科杂志》[ISSN:/CN:]
- 期数:
- 2011年03期
- 页码:
- 16
- 栏目:
- 基础研究
- 出版日期:
- 2011-07-30
文章信息/Info
- Title:
- Plasma neutrophil gelatinaseassociated lipocalin and diagnostic tool for septic complications after trauma
- Author(s):
- HAN Ming; LIN Zhexuan; DING Shan
- Department of Emergency,Second Affiliated Hospital,Medical College of Shantou University,Shantou515041,China
- 关键词:
- 创伤; 脓毒症; 中性粒细胞明胶酶相关脂质运载蛋白
- 分类号:
- R64
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的探讨血浆中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinaseassociate dlipocalin,NGAL）在创伤合并脓毒症诊断中的意义。方法2007年6月~2010年6月就诊的81例创伤病人。入院当时以及12、24、48小时采血，ELISA法检测血浆NGAL浓度。测定入院时血液白细胞计数。结果21例创伤合并脓毒症患者血浆NGAL水平显著高于无合并脓毒症患者（P<0.05）。以48小时内NGAL峰值绘制ROC曲线，曲线下面积为0.7198（P=0.0011）。入院时血浆NGAL水平与白细胞计数呈正相关。结论血浆NGAL浓度在一定程度上可鉴别患者是否合并脓毒症，可用于临床辅助诊断。
参考文献/References
［1］American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis［J］.Crit Care Med,1992,20(6):864-874.
［2］Kjeldsen L,Johnsen AH,Sengelov H,et al.Isolation and primary structure of NGAL,a novel protein associated with human neutrophil gelatinase［J］.J Biol Chem,1993,268:10425-10432.
［3］Bratt T,Ohlson S,Borregaard N.Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands［J］.Bioch im Biophys Acta,1999,1472(1-2):262-269.
［4］Xu S,Venge P.Lipocalins as biochemical markers of disease［J］.Biochim Biophys Acta,2000,1482(1-2):298-307.
［5］Bagshaw SM,Bennett M,Haase M,et al.Plasma and urine neutrophil gelatinaseassociated lipocalin in septic versus nonseptic acute kidney injury in critical illness［J］.Intensive Care Med,2010,36(3):452-461.
［6］Levy MM,Fink MP,Marshall JC,et al.2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference［J］.Crit Care Med,2003,31（4）:1250-1256.
［7］Wang ZG.The research progress of trauma［J］.J Clin Surg,2007,15（11）:727-730.
［8］Wang ZG.Advancement in research of trauma［J］.J Chengdu Med College,2006,1（1）:2-4.
［9］Bagshaw SM,George C,Bellomo R.Early acute kidney inury and sepsis: a multicentre evaluation［J］.Crit Care,2008,12(2):47.
［10］许丽艳,李恩民,熊华淇.NGAL的结构与功能研究进展［J］.生命科学,2002,14(1):27-29.
备注/Memo
- 备注/Memo:
- 基金项目：汕头市科技计划项目［汕府科（2008）85］资助作者单位：515041广东汕头，汕头大学医学院第二附属医院急诊科
