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|本期目录/Table of Contents|

PirB蛋白在中枢神经损伤修复中的作用

《创伤外科杂志》[ISSN:/CN:]

期数:
2017年19卷01期
页码:
74-76
栏目:
综述
出版日期:
2017-02-13

文章信息/Info

Title:
The roles of PirB in repair of central nervous system injuries
作者:
袁容娣; 范围
400037重庆，第三军医大学第二附属医院眼科
Author(s):
YUAN Rongdi; FAN Wei
Department of Ophthalmology,Xinqiao Hospital,Third Military Medical University，Chongqing 400037,China
关键词:
神经损伤; PirB蛋白; 抑制因子; 轴突再生
分类号:
R651
DOI:
-
文献标识码:
-
摘要:
【摘要】中枢神经系统损伤后再生困难的一个重要原因是因为髓鞘中存在与其相关的神经生长抑制性因子，而PirB蛋白是新发现的这些因子的共同受体。许多研究发现PirB在中枢神经系统中广泛表达，并参与调控神经元发育、生长导向及可塑性等作用，阻抑PirB功能后存在促进中枢神经系统神经再生修复的作用。深入了解PirB的功能可能为神经再生带来新的希望。

参考文献/References

［1］Berry M，Ahmed Z，Lorber B,et al.Regeneration of axons in the visual system［J］.Restor Neurol Neurosci,2008，26(2-3):147-174
［2］Wang KC,Koprivica V,Kim JA,et al.Oligodendrocytemyelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth［J］.Nature,2002，417(6892):941-944
［3］McKerracher L，David S，Jackson DL,et al.Identification of myelinassociated glycoprotein as a major myelinderived inhibitor of neurite growth［J］.Neuron,1994，13 (4):805-811
［4］Fujita Y，Yamashita T.Axon growth inhibition by RhoA/ROCK in the central nervous system［J］.Front Neurosci,2014,8:338
［5］Hayami K,Fukuta D,Nishikawa Y,et al.Molecular cloning of a novel murine cell surface glycoprotein homologous to killer cell inhibitory receptors［J］.J Biol Chem,1997,272 (11):7320-7327
［6］Takai T.Paired immunoglobulinlike receptors and their MHC class I recognition［J］ .Immunology,2005,115(4):433-440
［7］Matsushita H,Endo S,Kobayashi E,et al.Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIRB ectodomain provides an inhibition of cells［J］.J Biol Chem,2011,286(29):25739-25747
［8］Syken J,Grandpre T,Kanold PO,et al.PirB restricts ocular-dominance plasticity in visual cortex［J］.Science,2006,313(5794):1795-1800
［9］Adelson JD,Barreto GE,Xu L,et al.Neuroprotection from stroke in the absence of MHCI or PirB［J］.Neuron,2012,73(6):1100-1107
［10］Cai X,Yuan R,Hu Z,et al.Expression of PirB protein in intact and injured optic nerve and retina of mice［J］.Neurochem Res,2012,37(3):647-654
［11］Gou X,Zhang Q,Xu N,et al.Spatiotemporal expression of paired immunoglobulinlike receptorB in the adult mouse brain after focal cerebral ischaemia［J］.Brain Inj,2013,27 (11):1311-1315
［12］Geoffroy CG,Zheng B.Myelinassociated inhibitors in axonal growth after CNS injury ［J］.Curr Opin Neurobiol,2014,27:31-38
［13］Zheng B,Atwal J,Ho C,et al.Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo［J］.Proc Natl Acad Sci USA,2005,102(4):1205-1210
［14］Atwal JK,PinkstonGosse J,Syken J,et al.PirB is a functional receptor for myelin inhibitors of axonal regeneration［J］.Science,2008,322(5903):967-970
［15］Omoto S,Ueno M,Mochio S,et al.Genetic deletion of paired immunoglobulinlike receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury［J］.J Neurosci,2010,30(39):13045-13052
［16］Nakamura Y,Fujita Y,Ueno M,et al.Paired immunoglobulinlike receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury［J］.J Biol Chem,2011,286(3):1876-1883
［17］Fujita Y,Endo S,Takai T,et al.Myelin suppresses axon regeneration by PIRB/SHP mediated inhibition of Trk activity［J］.EMBO J,2011,30(7):1389-1401
［18］Dickson HM,Zurawski J,Zhang H,et al.POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66［J］.J Neurosci,2010,30(40):13319-13325
［19］Wang H,Xiong Y,Mu D.PirB restricts neuronal regeneration in developing rat brain following hypoxiaischemia［J］.Mol Med Rep,2012,6(2):339-344
［20］Bochner DN,Sapp RW,Adelson JD,et al.Blocking PirB upregulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia［J］.Sci Transl Med,2014,6(258):258ra140
［21］Djurisic M,Vidal GS,Mann M,et al.PirB regulates a structural substrate for cortical plasticity［J］.Proc Natl Acad Sci USA,2013,110(51):20771-20776
［22］Kim T,Vidal GS,Djurisic M,et al.Human LilrB2 is a betaamyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimers model［J］.Science,2013， 341(6152):1399-1404
［23］Ramasamy S,Yu F,Hong YY,et al.NogoR1 and PirB signaling stimulates neural stem cell survival and proliferation［J］.Stem Cells,2014,32(6):1636-1648

备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（81470630）
更新日期/Last Update: 2017-02-13