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口服丙酮酸盐-糖液对50%TBSA烧伤休克犬循环血容量和血乳酸水平的影响

《创伤外科杂志》[ISSN:/CN:]

期数:
2017年19卷01期
页码:
30-34
栏目:
论著（基础研究）
出版日期:
2017-02-13

文章信息/Info

Title:
Effects of pyruvate oral rehydration solution on lactate level and plasma volume during oral resuscitation in dogs with 50% TBSAfull thickness burn injury
作者:
白晓东; 刘维维; 周方强; 胡森
作者单位：100039北京，武警总医院烧伤整形科（白晓东，刘维维）；60008美国，芝加哥费森尤斯透析中心（周方强）；100048北京，解放军总医院第一附属医院烧伤研究所休克与多器官障碍实验室（胡森）
Author(s):
BAI Xiaodong1; LIU Weiwei1; ZHOU Fangqiang2; HU Sen3
1.Department of Burns and Plastic Surgery,General Hospital of Armed Police Force,Beijing 100039,China；2.Fresenius Dialysis Centers t Chicago, Chicago 60008, USA；3.Laboratory of Shock and Organ Dysfunction,Burns Institute, the First Hospital Affiliated to
关键词:
烧伤; 休克; 丙酮酸盐; 血容量; 酸中毒
分类号:
R644
DOI:
-
文献标识码:
A
摘要:
【摘要】目的 研究烧伤休克犬口服丙酮酸盐糖液对循环血容量和血乳酸水平的影响。方法24只Beagle 犬施行颈总动脉和颈外静脉置管及胃造口手术后24h，采用凝固汽油燃烧法造成50%总体表面积（TBSA）Ⅲ度 烧伤；将实验动物随机分为3组：单纯烧伤组（NR组，n=8，伤后不补液）、NaHCO-3盐-糖口服补液组（OH组 ，n=8）和丙酮酸盐糖口服补液组（OP组，n=8）。口服补液组于伤后30min根据Parkland公式经胃造口分 别输注NaHCO-3葡萄糖电解质液或丙酮酸盐葡萄糖电解质液。在动物清醒状态下测定平均动脉压(MAP)、循 环血浆容量(PV)、左心室内压最大变化速率(dp/dtmax)、血乳酸浓度、动脉血pH值、PaO2。结果 各组动物 的血流动力学等指标（MAP、PV、dp/dtmax、动脉pH值、血乳酸浓度、PaO2）于致伤后均降低；NR组各项指 标持续恶化，直至死亡；口服补液组各指标逐渐恢复，OP组显著优于OH组（P＜0.05）。结论 50%TBSA烧伤 犬口服补液时，丙酮酸盐糖液改善MAP、PV、dp/dtmax、动脉pH值、血乳酸浓度、PaO2的效果显著优于常 用的NaHCO-3盐-糖液。

参考文献/References

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备注/Memo

备注/Memo:
基金项目：军队十一五医学科研专项课题基金（06Z055）；发改办高技（2013）2140号重大灾害医学救援卫星综合应用服务示范
更新日期/Last Update: 2017-02-13